Analysis reveals that default mode network connectivity predicts antidepressant response in MDD, indicating potential biomarkers.
Key Points
Reduced effective connectivity from the medial prefrontal cortex to the posterior cingulate cortex predicts antidepressant response in major depressive disorder.
A cohort of 4271 patients showed that MDD patients exhibited lower connectivity compared to healthy controls, correlating with treatment outcomes.
Predictive accuracy for treatment response was high using support vector machine classifiers based on effective connectivity assessments.
The study offers insights into major depressive disorder neurobiology and the clinical application of default mode network measures.