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January 18, 2026npj Mental Health ResearchOpen Access

Beyond depression symptoms: the default mode network as a predictor of antidepressant response

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Authors

KZKaizhong ZhengLCLibin ChenHWHuaning Wang

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Overview

Investigation reveals DMN connectivity predicts treatment response in major depressive disorder, suggesting clinical relevance.

Key Points

  • This study aims to explore how default mode network connectivity relates to antidepressant response in major depressive disorder.
  • Analyzed resting-state fMRI data from four large cohorts with major depressive disorder
  • Examined effective connectivity within the default mode network using Granger causality
  • Compared connectivity measures across recurrent MDD patients, first-episode patients, and healthy controls
  • Employed support vector machine classifiers to predict treatment response based on connectivity data
  • Recurrent MDD patients showed significantly reduced effective connectivity from the medial prefrontal cortex to the posterior cingulate cortex compared to controls
  • Reduced connectivity correlated with antidepressant medication use and illness duration
  • Predictive models demonstrated high accuracy for predicting therapeutic outcomes based on DMN connectivity

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/696c789ceb60fb80d1396bb6https://doi.org/10.1038/s44184-025-00182-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Depression Symptoms: The Default Mode Network as a Predictor of Antidepressant Response2025 · 1 citations
  2. 2Resting-State Functional Connectivity of the Fronto-Limbic and Default Mode Networks as Predictors of Antidepressant Response in Major Depressive Disorder2025
  3. 3Baseline Default Mode Network Functional Connectivity as a Predictor of SSRI Treatment Response in Adolescent Major Depressive Disorder v12025
  4. 4Default Mode Network Reconfiguration Underlies Clinical Response to Amygdala-Targeted Neuromodulation in Major Depression2025
  5. 5Predictive neuroimaging biomarkers of major depressive disorder treatment response: An umbrella review2026