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This is a Quantitative Study study.

September 18, 2025Open Access

Single-Cell Transcriptomics Reveals Dynamics of NK Cell Expansion in a Feeder Cell-Free Culture of PBMCs - Implications for Immunotherapy

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This analysis reveals factors impacting NK cell growth in PBMCs, suggesting improvements for immunotherapy based on donor variability.

NK cell expansion variability was linked to donor factors and was most pronounced during days 3 to 8 of culture.
Single-cell transcriptomics identified specific phenotypes associated with high and low NK cell fractions.
The study found that inflammatory genes were upregulated in low NK cell fraction cultures, indicating stress responses.
Findings suggest potential markers for optimizing NK cell expansion, which could enhance therapeutic applications.

Ladd et al. (2025) studied this question.

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