TMSCl-Promoted Allylic Phosphorothiolation and Intermolecular Difunctionalization of Alkenes

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This is a Experimental Study study.

Chen Xu; Mingyang Chen; Qichao Yang; Xuesi Zhou; Wenbin Xu; Hua Cao; Xiang Liu

doi:10.1039/d5cc04576b

January 1, 2025Chemical Communications

TMSCl-Promoted Allylic Phosphorothiolation and Intermolecular Difunctionalization of Alkenes

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Key Points

The method successfully synthesizes structurally diverse s-alkyl phosphorothioates from various olefins, showcasing its versatility.
Using tmscl and n-phosphorothiosuccinimide, this process allows for a broad range of olefin classes to be utilized, indicating wide applicability.
A divergent strategy is highlighted, allowing access to differentiated products from similar precursors in a relatively straightforward manner.
The approach underscores the significance of phosphorothiolation in expanding the toolkit for organic synthesis, especially in the realm of functionalized compounds.

Abstract

Herein, we describe a TMSCl-promoted, divergent strategy for the synthesis of structurally diverse S-alkyl phosphorothioates from various classes of olefins using N-phosphorothiosuccinimide as the phosphorothiolation reagent. For aromatic trisubstituted and...

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d463e231b076d99fa62f2e https://doi.org/10.1039/d5cc04576b

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TMSCl-Promoted Allylic Phosphorothiolation and Intermolecular Difunctionalization of Alkenes

Key Points

Abstract

Discussion

Cite This Study

TMSCl-Promoted Allylic Phosphorothiolation and Intermolecular Difunctionalization of Alkenes

Key Points

Abstract

Discussion

Cite This Study

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