September 18, 2025Open Access

miRNAs as regulators of extracellular TLRs in bacterial infections

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Review highlights how bacterial infections alter TLR signaling, with miRNAs acting as regulators.

miRNAs influence the transcriptional response of TLRs during bacterial infections, affecting immune responses.
Certain bacteria change the signaling cascade of extracellular TLRs, complicating innate immunity interactions.
The role of miRNAs is complex, as many are downstream regulators while a few directly interact with TLRs.
Increased understanding of miRNA regulation by bacteria could support their use as biomarkers or in therapy.

Mancera et al. (2025) studied this question.

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