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Synthesize current evidence on how mammalian microRNAs regulate gene expression and host signaling pathways during bacterial infections.

June 1, 2012RNA BiologyOpen Access

The mammalian microRNA response to bacterial infections

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Review demonstrates dynamic microRNA regulation during bacterial invasion in mammalian hosts, highlighting novel targets for infection control.

Synthesize current evidence on how mammalian microRNAs regulate gene expression and host signaling pathways during bacterial infections.
Literature review of molecular studies assessing host microRNA expression changes following exposure to pathogenic bacteria.
Comparison of mammalian host responses elicited by intracellular, extracellular, Gram-negative, and Gram-positive pathogens.
Diverse bacterial pathogens, including Helicobacter pylori, Salmonella enterica, and Listeria monocytogenes, stimulate distinct changes in mammalian microRNA profiles.
Host microRNAs serve critical functions in regulating mammalian immune defense networks and downstream signaling cascades triggered by bacterial challenge.

Eulálio et al. (2012) studied this question.

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Review demonstrates dynamic microRNA regulation during bacterial invasion in mammalian hosts, highlighting novel targets for infection control.