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September 18, 2025Infection Genetics and EvolutionOpen Access

Targeted next-generation sequencing reveals pathogen mono- and co-detection patterns in pediatric Mycoplasma pneumoniae pneumonia

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Authors

GWGuangliang WuLonggang Central HospitalYZYuejie ZhengZunyi Medical UniversityKYKe YuanShenzhen Maternity and Child Healthcare Hospital

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Overview

Retrospective analysis reveals pathogen co-detection and resistance patterns in pediatric pneumonia, underscoring targeted next-generation sequencing's clinical value.

Key Points

  • Pathogen detection showed 99.7% identification rate in cases, with Mycoplasma pneumoniae representing 85.0% of detected pathogens.
  • The predominant drug resistance gene mutation observed was A2063G, present in 98.1% of 209 resistance gene cases.
  • Patients with Mycoplasma pneumoniae demonstrated significantly older ages than MP-carriage and MP-negative groups, indicating epidemiological shifts.
  • Atypical pathogens such as Tropheryma whipplei and Fusobacterium nucleatum were uncovered, pointing to the increasing complexity of pediatric pneumonia management.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68d463e231b076d99fa6304ehttps://doi.org/10.1016/j.meegid.2025.105832
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