Epidemiological analysis shows macrolide resistance in M. pneumoniae infections among Southern Chinese populations, suggesting critical public health implications.
Key Points
The research aims to investigate the epidemiological patterns and macrolide resistance in M. pneumoniae infections in Southern China.
Conducted targeted next-generation sequencing (tNGS) on samples from multiple medical centers
Analyzed over 58,000 specimens collected from January to December 2023
Examined macrolide resistance genes and co-infections with respiratory viruses
Characterized demographic and seasonal trends in infection rates
15.78% of specimens tested positive for M. pneumoniae
Significant gender differences: 19.06% in females vs 13.70% in males (P <0.001)
Children had the highest infection rates at 28.75%, with school-aged children (5-9 years) at 48.28%
Peak incidence observed in winter months at 25.88%
53.38% of children carried macrolide resistance genes, predominantly A2063G mutation