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September 18, 2025Deleted JournalOpen Access

Overview on adverse effects of bedaquiline containing regimens for drug resistant tuberculosis

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Review summarizes adverse drug reactions of bedaquiline for drug-resistant tuberculosis, highlighting QT prolongation issues.

The most common adverse drug reaction was QT prolongation, affecting 17.5% of patients.
Other notable adverse effects included hepatotoxicity at 13.2% and peripheral neuropathy at 9.5%.
A comprehensive literature search yielded 44 studies, with 34 included in the final analysis.
Vigilant monitoring is required during treatment due to significant adverse reactions associated with bedaquiline.

Kyaw et al. (2025) studied this question.

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