Optimization of Harumanis Mango Leaves Extract for Enhanced Pharmacognostic Profile Using Response Surface Methodology Approaches

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High concentrations of polyphenols and flavonoids indicate the potential of harumanis mango leaves for therapeutic use.
Ethanolic extract demonstrated stronger antioxidant activity with an IC50 value of 52.905 μg/mL compared to methanolic at 84.649 μg/mL.
Phytochemical screening confirmed the presence of essential bioactive compounds, supporting the leaves' medicinal characteristics.
Optimizing extraction methods highlights the potential for innovative applications in the pharmaceutical and herbal medicine industries.

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This analysis optimizes bioactive compounds in harumanis mango leaves, suggesting strong antioxidant and antibacterial effects.

Peron et al. (2025) studied this question.

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