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September 18, 2025Safety and Risk of PharmacotherapyOpen Access

Ketoprofen Comparative Pharmacokinetics Analysis in Humans and Animals: A Review

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Authors

EPE. M. PetrovaВКВ. М. КосманМКМ. В. Карлина

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Overview

Review assesses pharmacokinetics of ketoprofen in humans and animal models, suggesting optimal test systems.

Key Points

  • Ketoprofen pharmacokinetics showed comparable C max and T max between humans and several animals, enhancing study reliability.
  • Reversed-phase high-performance liquid chromatography was identified as the primary analytical method for ketoprofen in biomaterials.
  • Studies indicate the feasibility of using rats, cats, and dogs as relevant animal models for pharmacokinetics of ketoprofen.
  • Various routes of ketoprofen administration demonstrated high drug bioavailability, impacting pharmaceutical development.

Cite This Study

Petrova et al. (2025) studied this question.

synapsesocial.com/papers/68d463e931b076d99fa63428https://doi.org/10.30895/2312-7821-2025-497
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