Abstract C109: Single-nucleus sequencing reveals a functionally distinct breast tumor microenvironment by ancestral group with implications for disease progression and therapy
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Key Points
Women of African descent exhibited a more immune-suppressive tumor microenvironment, impacting disease outcomes.
Significant differences in tumor microenvironment characteristics were identified, which includes key immune and stromal cell types.
Single-nucleus sequencing successfully distinguished between cancerous and non-cancerous nuclei in 82 breast tumors.
Three predictive gene signatures for survival were developed, validated across other tissues, indicating clinical significance.
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Implication
Single-nucleus sequencing uncovers unique tumor microenvironments in women by genetic ancestry, suggesting implications for therapy.