Synthesis of novel 1-benzoylhexahydro-2H-pyrrolo[3,4-d]pyrimidine-2,4(3H)-dione

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This is a Experimental Study study.

Pavlo V. Melnychuk; Oleh Shablykin

doi:10.15407/bioorganica2025.01.046

June 30, 2025Ukrainica Bioorganica Acta

Synthesis of novel 1-benzoylhexahydro-2H-pyrrolo[3,4-d]pyrimidine-2,4(3H)-dione

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Key Points

The reaction achieved good yield, and regioselectivity was fully controlled during product synthesis.
Utilizing TFA catalysis, the 1,3-dipole was generated in situ and reacted efficiently with azomethine ylides.
This synthesis method highlights the advantages of using non-stabilized azomethine ylides in cycloaddition.
The novel product could have potential applications in medicinal chemistry and drug design.

Abstract

We report an efficient [3+2] cycloaddition involving non-stabilized electron-rich azomethine ylides and 1,3-dibenzoyl-pyrimidine-2,4(1H,3H)-dione. The 1,3-dipole was prepared in situ under TFA catalysis, and we obtained the product in good yield and with full control of the regioselectivity

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Melnychuk et al. (2025) studied this question.

synapsesocial.com/papers/68d463f131b076d99fa63a5b https://doi.org/10.15407/bioorganica2025.01.046

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Synthesis of novel 1-benzoylhexahydro-2H-pyrrolo[3,4-d]pyrimidine-2,4(3H)-dione

Key Points

Abstract

Discussion

Cite This Study

Synthesis of novel 1-benzoylhexahydro-2H-pyrrolo[3,4-d]pyrimidine-2,4(3H)-dione

Key Points

Abstract

Discussion

Cite This Study

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