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September 19, 2025Journal of Neural Engineering

Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies

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Authors

MSMichael Joseph Del SestoSNSerban NegoitaUniversity of FloridaMGMaria Bruzzone GiraldezUniversity of Florida

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Overview

This review explores neuromodulation benefits in neurological diseases, highlighting technological advancements and challenges faced for clinical adoption.

Key Points

  • Simultaneous targeting of multiple deep brain regions shows promise in improving neuromodulation outcomes.
  • Technological advancements, such as machine learning algorithms, could optimize stimulation parameters and device placement.
  • Despite potential benefits, significant barriers to the clinical adoption of these distributed brain interfaces remain.
  • The utilization of multi-site technologies addresses the needs of neurological diseases while requiring further innovation.

Cite This Study

Sesto et al. (2025) studied this question.

synapsesocial.com/papers/68d464e031b076d99fa63d9ahttps://doi.org/10.1088/1741-2552/ae08ea
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