Spectroscopic analysis shows thioamides improve hydrogen bond interactions in beta-strands, suggesting novel stability control methods.
Though thioamides are considered weaker hydrogen-bond acceptors than oxoamides, recent calculations suggest that they can enhance hydrogen bonds within the backbone of individual β-strands. We confirm this prediction through spectroscopic analysis of minimal amino-acid models. Further, incorporation of thioamides into the backbone of β-hairpin models highlights opportunities to control β-strand stability.
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Zheng et al. (2025) studied this question.
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