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September 19, 2025Open Access

Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways

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Authors

MVMarijana VujkovićDKDavid E. KaplanJGJonas Ghouse

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Overview

Genome-wide association study identifies novel loci linked to cirrhosis and hepatocellular carcinoma, suggesting unique progression pathways.

Key Points

  • A high genetic risk score for cirrhosis nearly doubles the risk of chronic liver disease progressing to cirrhosis.
  • The study identified 27 loci associated with cirrhosis, including 10 novel, and 11 loci for hepatocellular carcinoma, with three being novel.
  • Cirrhosis risk was modified by specific genetic variants after antiviral therapies in chronic hepatitis C patients.
  • Fifteen cirrhosis loci showed differential effects on cirrhosis risk depending on underlying etiologies and pathways.

Cite This Study

Vujković et al. (2025) studied this question.

synapsesocial.com/papers/68d464ea31b076d99fa64115https://doi.org/10.1101/2025.09.16.25335186
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Also Consider

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  1. 1Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patients2025
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  5. 5Genetic drivers of liver cirrhosis: The role of SERPINA1 and PNPLA3 variants in disease onset and progression2025 · 1 citations