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July 25, 2025Open Access

Genetic Variants in Liver Cirrhosis: A Review of Classification, Mechanisms, and Clinical Relevance Cirrhosis

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Authors

RRRoshni Pushpa RaghavanKAK AlexanderSSShine Sadasivan

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Overview

Review examines genetic variants involved in cirrhosis, revealing clinical implications and personalized approaches.

Key Points

  • Genetic factors are crucial in understanding cirrhosis heterogeneity and individualized risk assessment.
  • Critical genes like PNPLA3 and HSD17B13 are linked to cirrhosis risk through lipid dysregulation.
  • Ethnicity-associated polymorphisms further influence susceptibility to liver disease.
  • The review suggests integrating genetic profiling into hepatology for improved therapeutic targeting.

Cite This Study

Raghavan et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce413https://doi.org/10.20944/preprints202507.1705.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Variants in Liver Cirrhosis: Classifications, Mechanisms, and Implications for Clinical Practice2026 · 2 citations
  2. 2Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways2025 · 1 citations
  3. 3Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis2024 · 69 citations
  4. 4Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patients2025
  5. 5Genetic variants underlying precancerous conditions of hepatocellular carcinoma2025 · 5 citations