Elesclomol Diminishes Redox Deficit in Kidney of MBLAC1 Knockout Mice: A Fluorescence Imaging Study

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This is a Experimental Study study.

Parisa Nategh; Mehrnoosh Neghabi; Anna M. Stauffer; Randy Blakely; Mahsa Ranji

doi:10.1364/cleo_at.2025.jps100_8

January 1, 2025

Elesclomol Diminishes Redox Deficit in Kidney of MBLAC1 Knockout Mice: A Fluorescence Imaging Study

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Key Points

Elesclomol treatment reduced oxidative stress in MBLAC1 knockout mice, indicating strong therapeutic potential.
Cryo-imaging analysis revealed significantly lower NADH/FAD redox ratios in knockout mice kidneys compared to controls.
This fluorescence imaging study suggests elesclomol may have applications beyond its established role in cancer.
The findings highlight the role of redox balance under oxidative stress in kidney pathology and treatment.

Implication

Fluorescence imaging analysis shows elesclomol decreases oxidative stress in MBLAC1 knockout mice, suggesting new therapeutic uses.

Abstract

Cryo-imaging analysis revealed lower NADH/FAD redox ratios in MBLAC1 knockout mouse kidneys versus controls. Elesclomol treatment reduced oxidative stress, indicating potential therapeutic applications beyond its established role in cancer treatment.

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Cite This Study

Nategh et al. (2025) studied this question.

synapsesocial.com/papers/68d464f131b076d99fa644ac https://doi.org/10.1364/cleo_at.2025.jps100_8

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Elesclomol Diminishes Redox Deficit in Kidney of MBLAC1 Knockout Mice: A Fluorescence Imaging Study

Key Points

Implication

Abstract

Discussion

Cite This Study

Elesclomol Diminishes Redox Deficit in Kidney of MBLAC1 Knockout Mice: A Fluorescence Imaging Study

Key Points

Implication

Abstract

Discussion

Cite This Study

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