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September 19, 2025Open Access

Peroral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia: A Meta-Analysis of Randomized Controlled Trials

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Authors

HRHarshawardhan Dhanraj RamtekeHeart Rhythm SocietyKSKeerthi SanapalaAndhra UniversityADAshesh Kumar DasKPC Medical College and Hospital

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Overview

Meta-analysis of randomized controlled trials shows comparable dysphagia relief in achalasia, indicating careful consideration of GERD risk.

Key Points

  • Dysphagia improvement was similar between POEM and LHM in achalasia patients with no significant differences.
  • GERD incidence was higher after POEM, indicating potential reflux risk but not reaching statistical significance.
  • Clinical remission showed a non-significant trend favoring POEM, suggesting further investigation is needed.
  • POEM is linked to higher GERD risk with reduced pH levels significantly favoring LHM's outcomes.

Cite This Study

Ramteke et al. (2025) studied this question.

synapsesocial.com/papers/68d464f131b076d99fa645bfhttps://doi.org/10.1101/2025.09.16.25335767
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Also Consider

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  5. 5Fundoplication significantly improves objective and subjective reflux outcomes—a meta-analysis2025 · 7 citations