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September 19, 2025Acta OncologicaOpen Access

Balancing benefit and burden: treatment intensification in paediatric KMT2A rearrangements acute myeloid leukaemia

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Authors

HFHend FayezMEMariam ElsherifSSSherine Salem

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Overview

Retrospective analysis reveals KMT2A rearrangements and fusion partners significantly affect outcomes in pediatric AML.

Key Points

  • KMT2A rearrangements are linked to a 46% cumulative incidence of relapse compared to 30% in KMT2A-negative patients.
  • Five-year overall survival rates differ significantly, with KMT2A rearrangements having a 34% survival versus 53% in other groups.
  • KMT2A rearrangements are associated with hyperleukocytosis and complex karyotype, both of which adversely affect patient outcomes.
  • The study highlights that therapeutic strategies need to be intensified for patients with deleterious KMT2A rearrangements.

Cite This Study

Fayez et al. (2025) studied this question.

synapsesocial.com/papers/68d464ff31b076d99fa649b4https://doi.org/10.2340/1651-226x.2025.43878
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimized cytogenetic risk-group stratification of <i>KMT2A</i>-rearranged pediatric acute myeloid leukemia2024 · 30 citations
  2. 2Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study2024 · 34 citations
  3. 3Outcomes of acute lymphoblastic leukemia with <i>KMT2A</i> (<i>MLL</i>) rearrangement: the MD Anderson experience2021 · 53 citations
  4. 4Disease biology rather than donor type determines transplant outcomes in KMT2A-rearranged AML2026
  5. 5Research Progress on the KMT2A-AFF3 Fusion Gene in Childhood Acute Lymphoblastic Leukemia: Mechanisms, Clinical Implications, and Therapeutic Strategies2025