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September 19, 2025Doctor RuOpen Access

Features of the Metabolomic Profile in Gestational Diabetes Mellitus

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Authors

LGL.G. GazaryanIOI.M. OrdiyantsМLМ. G. Lebedeva

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Overview

Observational study reveals altered amino acid levels in gestational diabetes mellitus, suggesting potential biomarkers.

Key Points

  • The study found lower total urinary amino acid content in women with gestational diabetes mellitus (GDM).
  • Women with GDM showed higher levels of specific amino acids like glutamic acid and citrulline, but differences were not statistically significant.
  • A single-center observational study employed a case-control design comparing 24 GDM patients to 21 controls.
  • These findings may help identify metabolites in urine as biomarkers, enhancing understanding of GDM.

Cite This Study

Gazaryan et al. (2025) studied this question.

synapsesocial.com/papers/68d464ff31b076d99fa64ca0https://doi.org/10.31550/1727-2378-2025-24-5-63-67
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic and Proteomic Profiling of Women with Gestational Diabetes Mellitus2026 · 1 citations
  2. 2Amino Acid Profile Alterations in the Mother–Fetus System in Gestational Diabetes Mellitus and Macrosomia2025
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  4. 4Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus2025 · 6 citations
  5. 5Amino Acid Dysregulation in the Mother–Fetus Unit: Multi-Compartment Metabolomic Signatures of Gestational Diabetes Mellitus and Fetal Macrosomia2026 · 1 citations