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September 5, 2025International Journal of Molecular SciencesOpen Access

Amino Acid Profile Alterations in the Mother–Fetus System in Gestational Diabetes Mellitus and Macrosomia

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Authors

NFNatalia FrankevichATAlisa TokarevaSYS. Yu. Yuriev

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Overview

Analysis finds specific amino acid markers in the mother-fetus system, indicating GDM and macrosomia risk.

Key Points

  • Significant alterations in the amino acid profile were found in the mother-fetus system related to GDM and macrosomia.
  • Maternal serum increased 5-OH-lysine and homocitrulline in GDM, while cord blood showed higher isoleucine and serine.
  • Machine learning techniques and metabolic pathway analysis were utilized to identify 19 altered amino acids across samples.
  • Glutamine, histidine, and asparagine could serve as early biomarkers for predicting macrosomia in gestational diabetes.

Cite This Study

Frankevich et al. (2025) studied this question.

synapsesocial.com/papers/68bb42272b87ece8dc958fb9https://doi.org/10.3390/ijms26178351
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amino Acid Dysregulation in the Mother–Fetus Unit: Multi-Compartment Metabolomic Signatures of Gestational Diabetes Mellitus and Fetal Macrosomia2026 · 1 citations
  2. 2Features of the Metabolomic Profile in Gestational Diabetes Mellitus2025
  3. 3The association between circulating phenylalanine and the temporal risk of impaired insulin markers in gestational diabetes mellitus2024 · 4 citations
  4. 4Metabolic profiles in gestational diabetes mellitus can reveal novel biomarkers for prediction of adverse neonatal outcomes2024 · 6 citations
  5. 5Identifying serum amino acid as biomarkers of gestational diabetes mellitus in second-trimester among Chinese pregnant women: a machine learning-based cross-sectional study2026