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April 10, 2026International Journal of Molecular SciencesOpen Access

Amino Acid Dysregulation in the Mother–Fetus Unit: Multi-Compartment Metabolomic Signatures of Gestational Diabetes Mellitus and Fetal Macrosomia

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Authors

NFNatalia FrankevichNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian FederationATAlisa O. TokarevaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian FederationADAnna DerenkoNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

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Overview

Identifies amino acid alterations in gestational diabetes and fetal macrosomia, suggesting metabolic intervention targets.

Key Points

  • The study aims to explore how amino acid disturbances in the mother-fetus unit relate to gestational diabetes mellitus and fetal macrosomia.
  • Analyzed 62 mother-newborn dyads categorized by GDM and FM status.
  • Utilized Spearman test for associations with clinical parameters.
  • Identified amino acid markers using mutual information index and Mann–Whitney test.
  • Employed random forest method to analyze amino acid contributions via SHAP values.
  • GDM is linked to lower levels of glycine, 1-methylhistidine, γ-aminobutyric acid, lysine, and tryptophan in maternal serum.
  • Umbilical cord serum from GDM pregnancies showed reduced glutamine, glycine, asparagine, methionine, and proline.
  • GDM with FM led to increased lysine and 1-methylhistidine in amniotic fluid.
  • Fetal weight showed positive correlation with lysine and isoleucine and negative correlation with homocitrulline.

Cite This Study

Frankevich et al. (2026) studied this question.

synapsesocial.com/papers/69d895be6c1944d70ce06cc5https://doi.org/10.3390/ijms27083346
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