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May 22, 2026NutrientsOpen Access

Altered Maternal Fatty Acid Signature and Placental Transfer in Gestational Diabetes Mellitus: The Role of Fatty Acid Indices

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Authors

MBMagdalena Broś-KonopielkoABAgnieszka BiałekEREwa Romejko-Wolniewicz

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Overview

Cross-sectional study explores fatty acid composition and transfer in pregnancies with gestational diabetes mellitus, suggesting metabolic adaptations.

Key Points

  • The study aims to investigate the links between maternal serum lipid fatty acid composition, fatty acid indices, and placental fatty acid transfer in gestational diabetes mellitus.
  • Cross-sectional design involving 139 pregnant women (104 controls, 35 with GDM)
  • Maternal serum and umbilical cord blood samples collected at delivery
  • Fatty acid composition analyzed via gas chromatography; statistical adjustments for maternal age and BMI
  • Modest differences in fatty acid composition were noted, particularly for palmitoleic acid (C16:1)
  • Principal component analysis indicated some separation between GDM and control groups, with noted overlap
  • Variability in transplacental transport of α-linolenic acid observed; no consistent dietary pattern associations identified

Cite This Study

Broś-Konopielko et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff33bd674f7c03778bc7fhttps://doi.org/10.3390/nu18101624
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between the Serum Fatty Acids and Insulin in Gestational Diabetes2024 · 1 citations
  2. 2Advances in free fatty acid profiles in gestational diabetes mellitus2024 · 12 citations
  3. 3Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism2024
  4. 42140-P: Differential Fatty Acids in Human Milk from Individuals with Gestational Diabetes2026
  5. 5Expression of Placental Lipid Transporters in Pregnancies Complicated by Gestational and Type 1 Diabetes Mellitus2024 · 7 citations