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September 19, 2025ChemSci advances.

One–Pot Synthesis of Quinazolin–4(3H) –ones Catalyzed by 2,4,6–Trichloro–1,3,5–triazine (TCT) Under Solvent–Free Conditions

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Authors

DSDnyaneshwar M. SirsatHCHemant V. ChavanSSSamadhan A. Shenmare

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Overview

This method demonstrates a one-pot synthesis of quinazolin-4(3H)-ones using TCT, suggesting improved efficiency and sustainability in synthetic chemistry.

Key Points

  • The reaction yielded high product yields of 88–95% for quinazolin-4(3H)-ones under solvent-free conditions, showcasing significant efficiency.
  • Utilizing TCT as a catalyst in the multi-component synthesis of quinazolin-4(3H)-ones reduces hazardous waste and supports green chemistry principles.
  • This approach simplifies the synthetic process, eliminating intermediate isolation and shortens reaction times to just 50–70 minutes.
  • The synthesized quinazolin-4(3H)-ones are important for pharmaceuticals, demonstrating diverse biological activities including anticancer properties.

Cite This Study

Sirsat et al. (2025) studied this question.

synapsesocial.com/papers/68d466be31b076d99fa65ba1https://doi.org/10.69626/csa.2025.0235
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  2. 2Copper-Catalyzed Synthesis of Quinazolin-4(1H)-one from Amine-Trichloroacetonitrile Adduct and Isatoic anhydride2024 · 1 citations
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  4. 4Green and Efficient One-pot Synthesis of 2-Substituted Quinazolin-4( <i>3h</i> )-Ones by Using Scandium Triflate Catalyst2026
  5. 5Recent Advances in One-Pot Multicomponent Reactions for the Synthesis of Substituted Quinazolin-4(3H)-ones2025 · 11 citations