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September 20, 2025Journal of pharmacological and pharmaceutical research.

Ashwagandha (Withania somnifera) and Bone Health: A Narrative Review of Emerging Evidence and Mechanistic Insights

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Authors

MOMuhammad OwaisBacha Khan UniversityMMMuhammad ManzoorMUMuhammad UmarCOMSATS University Islamabad

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Implication

Narrative review explores the effects of ashwagandha on bone health, indicating potential benefits alongside traditional osteoporosis therapies.

Key Points

  • Ashwagandha's withanolides may help prevent bone loss in postmenopausal women, indicating a new treatment option.
  • Preclinical studies show ashwagandha enhances osteoblast function and reduces osteoclast activity, supporting bone health mechanisms.
  • Research highlights ashwagandha's ability to regulate cortisol and testosterone, suggesting hormonal benefits for bone density.
  • Limited human studies indicate that ashwagandha could lower bone-turnover markers in postmenopausal women, necessitating more research.

Cite This Study

Owais et al. (2025) studied this question.

synapsesocial.com/papers/68d469ba31b076d99fa66208https://doi.org/10.5455/jppr.20250730045230
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ashwagandha (Withania Somnifera): a comprehensive narrative review of its role in enhancing physical performance and health2026
  2. 2Effects of Ashwagandha Supplementation on Strength, Endurance, and Post-Exercise Recovery: A Review2025 · 1 citations
  3. 3Effects of Withania somnifera root extract on sleep quality, body composition, and menopausal symptoms in postmenopausal women: a randomized, double-blind, placebo-controlled trial2026
  4. 4Exploring the therapeutic potential of Ashwagandha (Withania somnifera) supplementation in alleviating stress and stress-related disorders2024 · 5 citations
  5. 5An Overview of Potential Benefits of Ashwagandha (Withania Somnifera) in Prevention and Treatment of Cervical Cancer2025