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September 20, 2025Open Access

Study on the anti-tumor effect of Wall-broken Ganoderma lucidum spore powder on papillary thyroid cancer

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Authors

LSLiuhong ShiSir Run Run Shaw HospitalLXLei XieCentral South UniversityJYJiangen YuThe First People's Hospital of Xiaoshan District, Hangzhou

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Implication

In vitro and in vivo analysis shows Ganoderma lucidum spores inhibit cancer cell proliferation and support apoptosis, indicating potential therapeutic benefits for papillary thyroid cancer.

Key Points

  • Ganoderma lucidum significantly inhibited PTC cell proliferation and induced apoptosis, showcasing its anti-tumor potential.
  • Treatment with Ganoderma lucidum spores suppressed migration and reversed epithelial-mesenchymal transition in various PTC cell lines.
  • This study utilized a nude mouse xenograft model to further corroborate the effective anti-tumor actions observed in vitro.
  • Findings highlight Ganoderma lucidum's traditional applications and its promise as a natural adjuvant therapy for cancer.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68d469c131b076d99fa665dehttps://doi.org/10.21203/rs.3.rs-7018011/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  3. 3Sporoderm‐broken spores of <i>Ganoderma lucidum</i> modulate hepatoblastoma malignancy by regulating <scp>RACK1</scp>‐mediated autophagy and tumour immunity2024 · 6 citations
  4. 4Ganoderma spore lipid ameliorates docetaxel, cisplatin, and 5-fluorouracil chemotherapy-induced damage to bone marrow mesenchymal stem cells and hematopoiesis2024 · 3 citations
  5. 5Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer2024 · 39 citations