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September 20, 2025Frontiers in PharmacologyOpen Access

Kaixin San Jiawei granule improves cognitive function and alleviates neuronal damage in Alzheimer’s disease via multi-component and multi-target mechanisms

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Authors

WLWei LiuYZYanan ZhaoTLTingting Liu

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Overview

Observational analysis shows improved cognitive function in Alzheimer's patients receiving kaixin san jiawei granule, indicating multi-target therapeutic potential.

Key Points

  • KSG significantly improved cognitive function and reduced neuronal damage in an Alzheimer’s model.
  • Treatment increased levels of acetylcholine and glutathione peroxidase while decreasing reactive oxygen species and acetylcholinesterase.
  • Network pharmacology analysis identified genistein and quercetin as key active compounds affecting core targets in Alzheimer's disease.
  • This study highlights how KSG may offer multi-target therapeutic strategies for treating Alzheimer's through traditional Chinese medicine.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d469ce31b076d99fa66a09https://doi.org/10.3389/fphar.2025.1650534
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