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This study investigates the efficacy and mechanisms of Kai-xin-san for treating Alzheimer's disease in animal models.

Efficacy and possible mechanism of Kai-xin-san in animal models of Alzheimer’s disease: a systematic review and meta-analysis of preclinical studies

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Systematic review reveals KXS enhances cognition in animal models of AD, indicating potential therapeutic benefits.

This study investigates the efficacy and mechanisms of Kai-xin-san for treating Alzheimer's disease in animal models.
Systematic search across 7 databases up to October 2025
Assessment of behavior and biomarkers as efficacy measures
Meta-analysis using STATA and RevMan software with risk of bias evaluation
KXS improved cognitive performance in MWM, NOR, and Y-maze tests
KXS significantly reduced Aβ, tau, and AchE levels; increased ACh and SOD in the hippocampus and serum
High risk of bias suggests reported effects may be overestimated

Wang et al. (2026) studied this question.

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