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August 27, 2020Frontiers in PharmacologyOpen Access

Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depression

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Why the study?

Depression and coronary heart disease often co-occur, but whether Kai-Xin-San exerts both antidepressive and cardioprotective effects in post-myocardial infarction depression had not been explored.

Does Kai-Xin-San (KXS) improve depression-like behaviors and cardiac function in a rat model of myocardial ischemia with depression?

Population

50 SD rats

Comparison

Control vs MI vs depression vs MI+depression vs MI+depression treated with 370 mg/kg KXS

Design

Randomized animal study

Follow-up

7 weeks

Authors

YHYuan HuQingdao UniversityXLXu LiuNanjing University of Chinese MedicineTZTianyi ZhangJiangsu University

Discussion

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Implication

KXS may confer dual benefits in rat MI-depression models; leaves open translation to human CHD with comorbid depression.

Structured PICO

Does Kai-Xin-San (KXS) improve depression-like behaviors and cardiac function in a rat model of myocardial ischemia with depression?

P
Population
50 male Sprague-Dawley (SD) rats, weighing 250-270 g, subjected to a model of myocardial ischemia (MI) with depression (induced by subcutaneous injection of 85 mg/kg isopropyl adrenaline and 7-week chronic mild stress).
I
Intervention
Kai-Xin-San (KXS) 370 mg/kg intragastric administration once a day for 21 days.
C
Comparator
MI+depression model group receiving the same volume of saline by intragastric administration.
O
Outcome
Depression-like behaviors (open-field test scores and sucrose consumption), cardiac function (EF and FS), and biochemical markers (CK-MB, LDH, SOD, GSH-PX, CAT, MDA, CRP, IL-6, TNF-α) after 7 weeks.surrogate

KXS demonstrates both antidepressant-like activity and cardioprotective effects in a rat model of post-myocardial infarction depression.

Cite This Study

Hu et al. (2020) studied this question.

synapsesocial.com/papers/6a765b3a6c15b6a2191b53c8https://doi.org/10.3389/fphar.2020.561817
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