Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 25, 2020Journal of EthnopharmacologyOpen Access

Kuanxiong aerosol inhibits apoptosis and attenuates isoproterenol-induced myocardial injury through the mitogen-activated protein kinase pathway

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The pharmacological mechanism of Kuanxiong aerosol in the prevention and treatment of myocardial injury is not clear.

Does Kuanxiong aerosol attenuate isoproterenol-induced myocardial injury in rats?

Population

Male Wistar Kyoto rats (age: 6 weeks, n = 6 per group across 5 groups)

Comparison

Kuanxiong aerosol (0.1 or 0.3 mL/kg) vs ISMN (5 mg/kg) vs ISO vs control

Design

Randomized animal experiment

Follow-up

14 days

Authors

YLYan LuInner Mongolia University of Science and TechnologyMYMeiling YangFujian Medical UniversityMPMeizhong PengBeijing University of Chinese Medicine

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for KXA in rat myocardial injury; human trials needed before clinical consideration.

Structured PICO

Does Kuanxiong aerosol attenuate isoproterenol-induced myocardial injury in rats?

P
Population
Male Wistar Kyoto rats (age: 6 weeks), n=30
I
Intervention
Kuanxiong aerosol (KXA) at low (0.1 mL/kg) or high (0.3 mL/kg) doses via intragastric administration for 14 days, with isoproterenol (ISO) (120 mg/kg) induced myocardial injury on the 13th and 14th days
C
Comparator
Control group (normal saline), ISO group (normal saline + ISO), and isosorbide mononitrate (ISMN) group (5 mg/kg + ISO)
O
Outcome
Electrocardiograms (ECGs), myocardial specific enzymes, histopathological changes, and apoptosissurrogate

Kuanxiong aerosol attenuates isoproterenol-induced myocardial injury in rats by inhibiting apoptosis mediated by the MAPK signaling pathway.

Cite This Study

Lu et al. (2020) studied this question.

synapsesocial.com/papers/6a815950b3060df1303bf1ffhttps://doi.org/10.1016/j.jep.2020.113757

Topics

Bremelanotide
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of c‐Jun N‐terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats2004 · 148 citations
  2. 2USP49 inhibits ischemia–reperfusion‐induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1–JNK1/2 signaling2018 · 32 citations