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April 25, 2025Frontiers in PharmacologyOpen Access

KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites

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Authors

FCFang ChenXYXiaoxia Yuan

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Overview

Randomized animal study demonstrates that KaiXinSan-JiaWei restores gut barrier integrity and increases butyric acid in APP/PS1 mice, suggesting brain-gut axis regulation improves cognitive deficits.

Key Points

  • Investigate the therapeutic efficacy and intrinsic mechanisms of the traditional herbal formula KaiXinSan-JiaWei on cognitive impairment and gut microbiota in an Alzheimer's disease mouse model.
  • Randomized 50 transgenic APP/PS1 mice (n=10 per group) into untreated model, donepezil (0.92 mg/kg/d), and low-, medium-, or high-dose KXSJW extract (0.9, 1.8, 3.6 mL/kg/d) groups, alongside 10 C57BL/6J wild-type saline-treated controls for two months.
  • Assessed learning and memory using the Morris Water Maze, profiled fecal microbes with 16S rRNA sequencing, quantified short-chain fatty acids by GC-MS, and examined intestinal mucosal integrity and serum gut peptides via immunohistochemistry and ELISA.
  • KXSJW treatment modulated gut microbial composition and significantly elevated levels of the major metabolite butyric acid compared to untreated model mice.
  • KXSJW repaired colonic mucosal barrier integrity and stimulated the circulating release of intestinal peptide hormones glucagon and GHRP-ghrelin in Alzheimer's model mice.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6a841c6ca47fb2e1cdb29534https://doi.org/10.3389/fphar.2025.1483883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and possible mechanism of Kai-xin-san in animal models of Alzheimer’s disease: a systematic review and meta-analysis of preclinical studies2026
  2. 2Kaixin San Jiawei granule improves cognitive function and alleviates neuronal damage in Alzheimer’s disease via multi-component and multi-target mechanisms2025 · 2 citations
  3. 3Exploring the multifaceted therapeutic mechanism of Schisanlactone E (XTS) in APP/PS1 mouse model of Alzheimer’s disease through multi-omics analysis2024 · 3 citations
  4. 4Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota2025
  5. 5In Vitro and In Vivo Evaluation of Kai-Xin-San Polysaccharides: Antioxidant, Anti-Inflammatory, and Anti-Alzheimer's Disease Activities2025