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September 10, 2025Frontiers in MicrobiologyOpen Access

Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota

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Authors

XLX LiuCSChaoqun SunYDYuqiong Dai

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Overview

Observation shows Danggui Shaoyao San enhances cognitive function in APP/PS1 mice, indicating its therapeutic role in gut microbiota dysbiosis.

Key Points

  • Danggui Shaoyao San effectively improves cognitive deficits in APP/PS1 mice and modulates gut microbiota.
  • Behavioral tests showed enhanced recognition memory and reduced anxiety with DSS treatment in mice.
  • 16S rRNA sequencing revealed DSS treatment restored gut microbiota diversity and increased beneficial bacteria.
  • DSS demonstrated potential in ameliorating AD-related symptoms, underpinning TCM's role in treating neurodegenerative disorders.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40f54b1d3bfb60de9b9https://doi.org/10.3389/fmicb.2025.1620784
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Also Consider

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  1. 1Danggui Shaoyao San and disassembled prescription: neuroprotective effects via AMPK/mTOR-mediated autophagy in mice2024 · 13 citations
  2. 2Danggui-Shaoyao-San modulates sphingolipid metabolism to promote oligodendrocyte differentiation and maturation in vascular dementia rats2025
  3. 3Danggui Shaoyao San ameliorates neuroinflammation in a D-galactose-induced Alzheimer’s disease rat model by suppressing the JAK2/STAT3 pathway and modulating Th17/Treg -related immune dysregulation2026
  4. 4Danggui Shaoyao San Alleviates Early Cognitive Impairment in Alzheimer's Disease Mice Through IRS1/GSK3β/Wnt3a‐β‐Catenin Pathway2024 · 4 citations
  5. 5KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites2025 · 5 citations