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February 28, 2026SHILAP Revista de lepidopterologíaOpen Access

Danggui Shaoyao San ameliorates neuroinflammation in a D-galactose-induced Alzheimer’s disease rat model by suppressing the JAK2/STAT3 pathway and modulating Th17/Treg -related immune dysregulation

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Authors

GFGangying FuSTShuyao TangXSXin Sun

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Overview

Demonstrates the effects of Danggui Shaoyao San on neuroinflammation in an Alzheimer’s model, suggesting potential therapeutic benefits.

Key Points

  • This research aims to evaluate the effects of Danggui Shaoyao San on neuroinflammation and immune dysregulation in an Alzheimer’s disease model.
  • Conducted in vivo experiments using Sprague-Dawley rats divided into treatment groups.
  • Induced Alzheimer’s disease using D-galactose injections.
  • Administered varying doses of Danggui Shaoyao San and donepezil over eight weeks.
  • Performed behavioral, biochemical, and histological assessments of treatment effects.
  • Applied network pharmacology and metabolomics for pathway exploration.
  • DSS treatment reduced neuronal damage and neuroinflammation in AD rats.
  • Improved learning and memory capabilities were observed post-treatment.
  • Th17 and Treg immune dysregulation were notably modulated by DSS.
  • Metabolomic analysis revealed disruptions in lipid and amino acid metabolism pathways.
  • DSS inhibited JAK2 and STAT3 activation, affecting pro-inflammatory cytokine production.

Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/69a285aa0a974eb0d3c00a67https://doi.org/10.3389/fcell.2026.1763180
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