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September 20, 2025PharmaceuticsOpen Access

Formulation Studies on Microemulsion-Based Polymer Gels Loaded with Voriconazole for the Treatment of Skin Mycoses

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Authors

MGMichał GackowskiAFAnna FroelichOKOliwia Kordyl

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Overview

Formulation study develops microemulsion gels for cutaneous delivery; VRC with menthol enhances antifungal effects.

Key Points

  • The optimized microemulsion gel effectively delivered voriconazole into human skin and demonstrated retention.
  • Voriconazole-loaded gels showed significant antifungal activity with larger inhibition zones against Candida albicans.
  • Ex vivo studies indicated increased deposition of voriconazole with menthol in both epidermis and dermis.
  • Microemulsion-based hydrogels produced non-Newtonian rheological properties, suitable for topical application.

Cite This Study

Gackowski et al. (2025) studied this question.

synapsesocial.com/papers/68d469ce31b076d99fa66ae1https://doi.org/10.3390/pharmaceutics17091218
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