The dual-modal GSTP probe detects glutathione s-transferase changes in diabetic mice, suggesting its potential for clinical diabetes monitoring.
We developed a dual-modal GSTP probe that exhibits GST-responsive fluorescence enhancement and photoacoustic signal reduction. GSTP demonstrated excellent selectivity, sensitivity, and biocompatibility. In diabetic mice, GSTP revealed a decreased level of hepatic GST activity partially restored by metformin treatment, supported by serum analysis and histopathological evaluation, highlighting its clinical translation potential for diabetes monitoring.
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He et al. (2025) studied this question.
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