September 20, 2025ImmunoHorizonsOpen Access

Genetic deletion of Alx/Fpr2 differentially regulates pulmonary inflammation in the absence and presence of acute lung injury

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Genetic deletion of Alx/Fpr2 affects inflammatory cytokines and immune cell populations in pulmonary injury, suggesting context-dependent roles.

Alx/Fpr2 KO mice displayed increased pulmonary inflammation but protection during prolonged lung injury.
Lipidomic analysis revealed higher oxylipin levels in KO mice, indicating altered metabolism.
Flow cytometry results showed significant increases in NK cells and monocytes, highlighting a proinflammatory state.
After LPS-induced acute lung injury, KO mice exhibited elevated IL-1β and lower inflammatory cytokines at 72 hours.

Virk et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Genetic deletion of Alx/Fpr2 affects inflammatory cytokines and immune cell populations in pulmonary injury, suggesting context-dependent roles.