Why the study?
Splenic leukocyte-directed specialized proresolving mediators are essential for cardiac repair after injury, but their target remained undefined in cardiac healing and repair.
Does the lack of ALX/FPR2 drive age-related cardiometabolic defects and impede inflammation resolution in heart failure?
Population
ALX/FPR2-null mice
Design
Preclinical animal study
Authors
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Resolvin D1–ALX/FPR2 signaling may aid splenic inflammation resolution in aged mice; leaves open translation to human cardiac repair.
Does the lack of ALX/FPR2 drive age-related cardiometabolic defects and impede inflammation resolution in heart failure?
The ALX/FPR2 receptor is essential for resolving cardiac inflammation, preventing obesogenic cardiomyopathy, and maintaining cardiorenal homeostasis during aging and after myocardial infarction.
Tourki et al. (2019) studied this question.
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