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September 20, 2025Frontiers in PhysiologyOpen Access

Identification of key lipid metabolism-related genes in kidney fibrosis: implications for chronic kidney disease management

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Authors

QCQiuyu CaoLLLonghui LiuSZSai Zhou

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Overview

Analysis identifies lipid metabolism-related genes to improve chronic kidney disease outcomes, highlighting biomarkers and immune implications.

Key Points

  • Identified six core lipid metabolism-related genes significantly associated with kidney fibrosis.
  • Constructed a diagnostic model achieving AUC values of 0.723 to 0.774 for predicting kidney fibrosis subtypes.
  • Utilized machine learning and enrichment analysis to reveal immune cell infiltration correlations.
  • Categorized kidney fibrosis samples into three distinct lipid metabolism-related clusters for improved management.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa67775https://doi.org/10.3389/fphys.2025.1652513
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