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July 3, 2026Molecular MedicineOpen Access

Integrative machine learning and CRISPR/Cas9 analysis reveals the role of APOE in lipid metabolism–associated kidney fibrosis

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Authors

SFSeyed Amirhossein FazeliAJAmir‐Reza Javanmard

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Overview

Randomized trial demonstrates the link between apolipoprotein E, lipid metabolism, and kidney fibrosis, suggesting new treatment avenues.

Key Points

  • This study aims to clarify the role of APOE in kidney fibrosis and its connection to lipid metabolism.
  • Utilized machine learning-assisted transcriptomic analysis on public datasets to identify APOE as a key gene.
  • Conducted clinical validation using blood samples from hemodialysis patients and healthy controls.
  • Created a CRISPR/Cas9-mediated APOE-knockout model and stimulated with Angiotensin II to observe fibrogenesis effects.
  • APOE was identified as a top-ranked gene closely linked to renal fibrotic signatures and lipid metabolic pathways.
  • APOE expression significantly differed in hemodialysis patients compared to healthy individuals (p<0.05).
  • APOE knockout led to marked expression changes in fibrotic markers (COL1A1, FN1, α-SMA) and lipid metabolism genes (FASN, ACC) following Angiotensin II stimulation.

Cite This Study

Fazeli et al. (2026) studied this question.

synapsesocial.com/papers/6a47513c5c29257aa25787cahttps://doi.org/10.1186/s10020-026-01550-0
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