Single-cell transcriptomics reveals apolipoprotein A4-mediated metabolic-immune reprogramming in lymphocytes during early obesity-related chronic kidney disease.
Single-cell transcriptomics reveals immune dysregulation among lymphocytes in chronic kidney disease, suggesting apolipoprotein A4 is a key metabolic regulator.
Key Points
Apolipoprotein A4 deletion leads to exacerbated insulin resistance and altered immune functions in lymphocytes.
Single-cell RNA sequencing shows remodeling of the immune-metabolic landscape in chronic kidney disease.
Apolipoprotein A4 is vital for maintaining lymphocyte metabolic and immune homeostasis early in kidney disease.
The study integrates multiple techniques like flow cytometry and qPCR to support findings on immune signaling disruptions.