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September 20, 2025Frontiers in OncologyOpen Access

Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial

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Authors

FSFlorian ScheppSHSebastian HempelFBFelix von Bechtolsheim

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Overview

Retrospective trial reveals CA19-9 values significantly predict resectability in patients, suggesting improved preoperative strategies.

Key Points

  • Patients with CA19-9 values below 105 U/ml have a significantly higher chance of curative resection.
  • The combination of specific CA19-9 thresholds can increase the resectability rate to 93%, indicating strong predictive value.
  • Utilizing propensity score matching, the analysis effectively distinguished between resectable and unresectable cases in borderline scenarios.
  • These findings underscore the importance of accurate biomarkers in reducing futile surgical interventions for patients.

Cite This Study

Schepp et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa6795bhttps://doi.org/10.3389/fonc.2025.1602933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Ca19-9 reduction on resectability and survival in pancreatic cancer patients following neoadjuvant or conversion chemotherapy.2026
  2. 2Significance of Preoperative Chemotherapy and Chemoradiotherapy in Patients With Locally Advanced and Borderline Resectable Pancreatic Cancer2025
  3. 3ASO Author Reflections: Importance of Preoperative Prediction of Survival in Resectable Pancreatic Ductal Adenocarcinoma2024 · 1 citations
  4. 4Outcomes of surgery for borderline and locally advanced pancreatic cancer following neoadjuvant chemotherapy2025
  5. 5The Value of Biological and Conditional Factors for Staging of Patients with Resectable Pancreatic Cancer Undergoing Upfront Resection: A Nationwide Analysis2024 · 11 citations