What question did this study set out to answer?

This review aims to analyze current and innovative treatment methods for borderline resectable and locally advanced pancreatic cancer, focusing on downstaging for surgical resection.

April 3, 2026CancersOpen Access

Systematic Review and Meta-Analysis of Current and Novel Approaches in the Management of Borderline Resectable and Locally Advanced Pancreatic Cancer

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This review aims to analyze current and innovative treatment methods for borderline resectable and locally advanced pancreatic cancer, focusing on downstaging for surgical resection.
Conducted a systematic search of multiple medical databases for relevant articles.
Included primary studies on therapies leading to downstaging of borderline resectable and locally advanced pancreatic cancer.
Utilized a random-effects model based on the inverse variance method for meta-analyses.
Included 88 studies with a total of 8585 patients, predominantly from retrospective studies.
Neoadjuvant therapy with chemotherapy or radiotherapy achieved the highest R0 resection rates.
Chemotherapy alone showed significant survival benefits compared to non-operative management (HR 0.33).
No significant differences in survival benefits were found among different therapy modalities.

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Implication

Systematic review demonstrates survival benefits of neoadjuvant therapy in borderline resectable and locally advanced pancreatic cancer, suggesting improved management strategies.

Cite This Study

Le et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e745a333a821460cc69 https://doi.org/10.3390/cancers18071139

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Implication

Systematic review demonstrates survival benefits of neoadjuvant therapy in borderline resectable and locally advanced pancreatic cancer, suggesting improved management strategies.

Systematic Review and Meta-Analysis of Current and Novel Approaches in the Management of Borderline Resectable and Locally Advanced Pancreatic Cancer

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Discussion

Implication

Cite This Study

Systematic Review and Meta-Analysis of Current and Novel Approaches in the Management of Borderline Resectable and Locally Advanced Pancreatic Cancer

Key Points

Discussion

Implication

Cite This Study

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