What question did this study set out to answer?

The aim is to evaluate the effectiveness of total neoadjuvant approaches in borderline resectable and locally advanced pancreatic ductal adenocarcinoma.

May 16, 2026CancersOpen Access

Total Neoadjuvant Approach for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma—UK Tertiary Cancer Centre Experience

View Full Paper

Ask AI

Bookmark

The aim is to evaluate the effectiveness of total neoadjuvant approaches in borderline resectable and locally advanced pancreatic ductal adenocarcinoma.
Single-centre retrospective analysis of 165 patients, including 44 with borderline resectable and 121 with locally advanced PDAC.
Patients received neoadjuvant treatment with systemic anti-cancer therapies and/or chemoradiation followed by surgical resection.
Data collected from June 2017 to September 2022.
Median overall survival was comparable at 18 months for borderline resectable and 16 months for locally advanced patients (p = 0.14).
47.7% of borderline resectable patients and 18.1% of locally advanced patients were suitable for surgical resection after neoadjuvant therapy.
For resected patients, R0 resection showed a significant overall survival advantage compared to R1 (47 vs. 22 months, p < 0.001).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Retrospective analysis examines survival outcomes in borderline resectable and locally advanced pancreatic cancer patients, suggesting effective treatment strategies.

Cite This Study

Yeung et al. (2026) studied this question.

synapsesocial.com/papers/6a0809d7a487c87a6a40ba3e https://doi.org/10.3390/cancers18101597

View Full Paper

Ask AI

Bookmark

Implication

Retrospective analysis examines survival outcomes in borderline resectable and locally advanced pancreatic cancer patients, suggesting effective treatment strategies.

Total Neoadjuvant Approach for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma—UK Tertiary Cancer Centre Experience

Key Points

Discussion

Implication

Cite This Study

Total Neoadjuvant Approach for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma—UK Tertiary Cancer Centre Experience

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider