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September 20, 2025Briefings in BioinformaticsOpen Access

Computational refinement and multivalent engineering of complementarity-determining region-grafted nanobodies on a humanized scaffold for retaining antiviral efficacy

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Authors

LHLiyun HuoQQQin QinTTTian Tian

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Overview

Computational refinement improves binding affinity in humanized nanobodies, suggesting potential for antiviral applications.

Key Points

  • Three optimized nanobody variants retained potent neutralizing activity against SARS-CoV-2.
  • CDR-grafting on a humanized scaffold led to improved humanness scores in nanobody variants.
  • Multivalent constructs displayed picomolar neutralizing potency compared to the original Nb2-67.
  • The study introduces a novel strategy for developing nanobody therapeutics targeting COVID-19.

Cite This Study

Huo et al. (2025) studied this question.

synapsesocial.com/papers/68d46abb31b076d99fa67ee0https://doi.org/10.1093/bib/bbaf477
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