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Stem cell therapy for cardiovascular diseases: Mechanisms, challenges, and therapeutic prospects

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Stem cell therapy promotes healing in cardiovascular diseases by restoring cardiac function post-myocardial infarction.
Key cell types include cardiac progenitor cells, mesenchymal stem cells, and induced pluripotent stem cells involved in healing processes.
Challenges such as poor cell retention, immune rejection, and potential tumor formation limit clinical applications of the therapy.
The exploration of mechanisms like paracrine signaling and angiogenesis is critical for enhancing the effectiveness of therapies.

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Review highlights advances in stem cell therapy for cardiovascular diseases, suggesting various mechanisms and challenges.

Abraham et al. (2025) studied this question.

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