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September 17, 2025Journal of Inflammation ResearchOpen Access

Investigation of Antioxidant Enzymes (GST, GSH, R-GSSG) in Erythrocytes of COVID-19 Patients: A One-Month Observation

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Authors

ECElżbieta Cecerska‐HeryćNSNatalia SerwinEPEwa Pius‐Sadowska

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Overview

This observational study finds altered antioxidant enzyme levels in COVID-19 patients, suggesting a link to mortality risk.

Key Points

  • COVID-19 patients show significantly lower levels of glutathione, indicating increased oxidative stress and potential mortality risk.
  • Glutathione concentration decreased significantly (p < 0.001), while R-GSSG and GST activities increased (p = 0.046), linking to disease severity.
  • Blood samples collected from 85 COVID-19 patients were compared to those of 85 healthy individuals over a month, highlighting oxidative stress's role.
  • The findings support the hypothesis that oxidative stress contributes to worsened outcomes in COVID-19, especially for older patients.

Cite This Study

Cecerska‐Heryć et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa69175https://doi.org/10.2147/jir.s523607
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Redox Biomarkers – An Effective Tool for Diagnosing COVID-19 Patients and Convalescents2024 · 4 citations
  2. 2A decrease in the concentration of free blood glutathione in the acute phase of coronavirus infection2024
  3. 3Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers2024
  4. 4A Systematic Review of Genetic Variants in Glutathione S-Transferase Genes and Their Dual Role in SARS-CoV-2 Pathogenesis: From Acute Respiratory Complications to Long COVID2025 · 3 citations
  5. 5The role of disturbed redox homeostasis in COVID-192025