Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 4, 2025AntioxidantsOpen Access

A Systematic Review of Genetic Variants in Glutathione S-Transferase Genes and Their Dual Role in SARS-CoV-2 Pathogenesis: From Acute Respiratory Complications to Long COVID

View Full Paper
Ask AI
Bookmark
Share

Authors

VSVioleta SánchezUniversidad de La SabanaJCJuan Luís Chávez-PachecoInstituto Nacional de PediatriaMPMargarita Isabel Palacios‐ArreolaInstituto Nacional de Enfermedades Respiratorias

Discussion

Loading...

Member takes

Overview

Systematic review evaluates glutathione s-transferase genetic variants and oxidative stress in covid-19, suggesting implications for long covid effects.

Key Points

  • GST gene polymorphisms exhibit inconsistent effects on covid-19 severity and long covid outcomes.
  • Oxidative stress is prevalent in patients with long covid, indicating a potential underlying mechanism.
  • A systematic search identified ten relevant studies, highlighting the need for further investigation of GST subfamilies.
  • Further understanding of GST variants may improve insights into covid-19 pathogenesis and long covid development.

Cite This Study

Sánchez et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0dd3https://doi.org/10.3390/antiox14080912
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of GSTM1 and GSTT1 Null Genotypes with Disease Severity and Serum Cytokine Levels in Hospitalized COVID-19 Patients2026
  2. 2Investigation of Antioxidant Enzymes (GST, GSH, R-GSSG) in Erythrocytes of COVID-19 Patients: A One-Month Observation2025 · 1 citations
  3. 3Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID2023 · 7 citations
  4. 4Association of superoxide dismutase and catalase genetic variants and their gene-gene interactions with the severity of COVID-192024 · 1 citations
  5. 5The role of disturbed redox homeostasis in COVID-192025