Key result
Carriers of any two variant alleles of GPX1, GPX3, or Nrf2 had a significantly lower risk of developing dyspnea in long COVID compared to referent allele carriers (OR 0.273, p=0.016).
Why the study?
Although redox homeostasis disturbance may cause COVID-19 cardiac complications, the role of antioxidant protein polymorphisms in susceptibility to long COVID cardiac manifestations had not been addressed.
Do antioxidant genetic variants (SOD2, GPX1, GPX3, Nrf2) modify the risk of subclinical cardiac dysfunction and symptoms in convalescent COVID-19 patients?
Population
174 convalescent COVID-19 patients
Comparison
Antioxidant protein polymorphisms (SOD2, GPX1, GPX3, Nrf2) variant vs referent alleles
Design
Observational study
Authors
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May inform redox-related risk stratification in long COVID; leaves open causal validation and clinical utility.
Observational (n=174)
Do antioxidant genetic variants (SOD2, GPX1, GPX3, Nrf2) modify the risk of subclinical cardiac dysfunction and symptoms in convalescent COVID-19 patients?
Odds Ratio: 0.273
p-value: p=0.016
Antioxidant genetic variants, particularly in GPX and SOD2, are associated with altered echocardiographic indices and reduced dyspnea risk in long COVID, suggesting a genetic propensity for post-COVID cardiac manifestations.
Ašanin et al. (2023) conducted an observational in Long COVID-19 (n=174). Antioxidant genetic variants (SOD2, GPX1, GPX3, Nrf2) vs. Referent alleles was evaluated on Dyspnea development (OR 0.273, p=0.016). Carriers of any two variant alleles of GPX1, GPX3, or Nrf2 had a significantly lower risk of developing dyspnea in long COVID compared to referent allele carriers (OR 0.273, p=0.016).
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