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August 4, 2020European Heart JournalOpen Access

Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study

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Why the study?

Although COVID-19 has been linked to myocardial involvement, elevated troponin, and acute heart failure with reduced ejection fraction, the underlying cardiac pathological changes were not well described.

Population

21 consecutive COVID-19 autopsy cases

Design

International multicentre pathology study

Authors

OLOrnella LeoneMGMonica De GaspariAWAllard C. van der Wal

Discussion

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Overview

Autopsy data on myocardial changes in COVID-19; leaves open clinical relevance and need for prospective studies in survivors.

Structured PICO

P
Population
21 consecutive COVID-19 patients who underwent autopsy
O
Outcome
Presence of myocarditis (defined by multiple foci of inflammation with associated myocyte injury) and inflammatory cell compositionsurrogate

Autopsy findings of COVID-19 patients reveal that while interstitial macrophage infiltration is common, true lymphocytic myocarditis is present in only a small fraction (14%) of cases.

Cite This Study

Leone et al. (2020) studied this question.

synapsesocial.com/papers/6a7caedbf108d7d7faba4b2dhttps://doi.org/10.1093/eurheartj/ehaa664
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